Proven Efficacy
Natural anti-stress performance providing mood elevation without cognitive or physical sedation.
Standardized Botanical Extract
SCUTELL'UP®
Safe, Non-Addictive Anxiolytic & Cognitive Potential Enhancer
Botanical Active Innovation
A Safe and Non-Addictive Natural Anxiolytic
Global consumer data indicates that up to 50% of adults worldwide report experiencing moderate to severe stress at least three times per week. Conventional pharmaceutical anxiolytics are frequently associated with undesirable adverse effects, including motor incoordination, tolerance, and physical dependency.
To meet the growing demand from health-conscious consumers seeking natural stress relief solutions, Green Plants Extracts (GPE) developed SCUTELL'UP® — a premium botanical active ingredient extracted from Scutellaria baicalensis Georgi roots. Standardized to high-purity flavones (≥85% Baicalin), SCUTELL'UP® efficiently mitigates stress and anxiety without inducing sedative effects or rebound anxiety upon cessation.
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Key Formulating Advantages of SCUTELL'UP®
Formulator Excellence
Why Choose SCUTELL'UP® for Your Next Formulation
Rapid Onset
Demonstrated biological action within 2 hours, maintaining mental clarity under stress conditions.
Zero Habituation
No dependency formation, no tolerance build-up, and zero rebound anxiety upon treatment withdrawal.
High Safety Profile
Complete traceability control, clean safety record, non-addictive profile supported by peer-reviewed literature.
Premium Quality
Standardized raw material quality featuring high active purity (Baicalin ≥ 85% by HPLC assay).
Scientific Evidence & Mechanism
Clinically Supported Biological Activity
SCUTELL'UP® acts through targeted biological pathways to protect the HPA axis and support neurological stability under acute and chronic stress.
Targeted Mechanism of Action
Unlike non-selective GABAergic agents, Scutellaria baicalensis flavones exert highly selective physiological actions:
- Selective Partial Agonism of GABAA α Receptors: Binds selectively to α-subunits of GABAA receptors, mimicking anxiolytic pathways without the sedative side-effects associated with benzodiazepines.
- Systemic Cytokine & Inflammation Reduction: Suppresses pro-inflammatory cytokines linked to stress-induced mood disturbances and neuroinflammation.
- Neurogenesis & Neuronal Differentiation: Promotes precursor cell proliferation in hippocampal tissues, aiding resilience to mental fatigue.
Stress Hormone & Memory Studies
Rigorous pre-clinical evaluation confirms SCUTELL'UP®'s rapid and sustained biological impact:
- Reduction of Corticosterone Levels: Plasma corticosterone (stress hormone) elevated during Chronic Mild Stress (CMS) is reversed as effectively as pharmaceutical reference drugs (such as Fluoxetine).
- No Cognitive or Motor Impairment: In passive avoidance step-through latency testing, Baicalin demonstrated zero impairment of memory retention or motor coordination, contrasting sharply with traditional sedative-anxiolytic controls.
Clinical Result: Significant stress response modulation observable within 2 hours of intake and sustained over continuous 2-week administration.
Manufacturing Dossier
Technical Specifications
Commercial Name
SCUTELL'UP®
Botanical Origin
Scutellaria baicalensis Georgi (Root extract)
Standardization / Active Assay
Baicalin ≥ 85% (Assayed by HPLC)
Physical Appearance
Fine Yellowish Powder, Water-Soluble
Recommended Daily Dosage
20 mg — 1 to 3 times per day (acute use or 3–6 week dietary supplementation cycles)
Target Formulations
Hard gelatin capsules, tablets, softgels, sachets, functional beverages, and liquid food supplements
Quality Standards
ISO 9001 / ISO 14001, GMP Certified, Non-GMO, Halal & Kosher Compliant
Peer-Reviewed Bibliography & References
- Pang et al. (2016). Multiple-Ascending-Dose Pharmacokinetics and Safety Evaluation of Baicalein Chewable Tablets in Healthy Volunteers. Clin Drug Investig.
- Brock et al. (2014). American Skullcap (Scutellaria lateriflora): A Randomised, Double-Blind Placebo-Controlled Crossover Study of its Effects on Mood in Healthy Volunteers. Phytother Res.
- Pao et al. (2012). Chinese herbal medicines promote neuroproliferation in vitro, and reverse the effects of chronic mild stress on behavior and HPA axis in vivo. Journal of Ethnopharmacology.
- Zhou et al. (2019). Baicalin regulates the dopamine system to control the core symptoms of ADHD. Molecular Brain.
- Chang et al. (2011). Biphasic effects of baicalin, an active constituent of Scutellaria baicalensis Georgi, in spontaneous sleep-wake regulation. Journal of Ethnopharmacology.
- Shin et al. (2014). Preventive effects of skullcap (Scutellaria baicalensis) extract in a mouse model of food allergy. Journal of Ethnopharmacology.
- Limanaqi et al. (2020). Potential Antidepressant Effects of Scutellaria baicalensis, Hericium erinaceus and Rhodiola rosea. Antioxidants.
- Wang et al. (2008). GABA(A) receptor subtype selectivity underlying selective anxiolytic effect of baicalin. Neuropharmacology.
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