A Next-Generation Centella Asiatica Extract Promoting Optimal Brain Functions
Global life expectancy has increased by nearly 25 years over the past century. As populations age, preserving long-term cognitive health and mental sharpness has become a top commercial priority for nutraceutical brand owners. Surveys show that over 75% of adults actively fear age-related memory decline and cognitive slowing.
As a pioneer in clinically validated botanical ingredients, Green Plants Extracts (GPE) developed CENTELLORY® — a premium, dual-standardized Centella asiatica (Gotu Kola) extract designed to support executive function, memory consolidation, and long-term neuroprotection.
Built on Science, Safety, and Dual Standardization
Clinical Efficacy
Acts as a proven memory enhancer and natural mild anxiolytic backed by double standardization.
Premium Quality
Strict raw material selection ensuring high chemical constancy in every batch.
Safety Profile
100% full supply chain traceability control with zero reported adverse side effects at clinical dosages.
Health Benefits
Dually supports cognitive performance, reaction speed, focus, and overall cellular recovery.
Dual Target Market
Ideal for healthy seniors seeking memory retention as well as younger demographics needing cognitive stamina.
Comprehensive Brain Health Benefits
CENTELLORY® provides multi-targeted neurological support across multiple functional domains.
Anxiety & Stress Relief
Modulates stress pathways to promote a calm, composed mental state without sedation or loss of mental acuity.
Memory & Learning Enhancement
Facilitates information processing speed, word recall, and long-term memory formation in healthy adults.
Neuroprotective Action
Shields neural cells against oxidative stress, reducing neuroinflammation and structural neuronal degeneration.
Alertness for Seniors
Improves visual choice reaction time, working memory accuracy, and self-reported calmness in elderly subjects.
Biochemical Mechanisms of Action
- Modulates nitric oxide synthesis
- Increases GABA neurotransmitter release
- Regulates the hypothalamo-pituitary-adrenocortical (HPA) axis
- Decreases pro-inflammatory TNF-α levels
- Elevates Brain-Derived Neurotrophic Factor (BDNF)
- Significantly increases synaptic density
- Boosts hippocampal BDNF expression
- Upregulates AMPAR subunits
- Optimizes NMDAR subunit expression for synaptic plasticity
- Attenuates amyloid-β accumulation
- Suppresses acetylcholinesterase activity
- Prevents ultrastructural neuron morphological aberrations
Technical & Commercial Dossier
| Commercial Name | CENTELLORY® |
|---|---|
| Botanical Source | Centella asiatica (L.) Urb. (Aerial parts) |
| Active Standardization | Triterpenoids ≥ 20% | Polyphenolic Compounds ≥ 10% |
| Physical Form | Fine Powder |
| Recommended Dosage | 200 mg / day (typical treatment duration: 3 to 6 weeks) |
| Solubility Profile | Partially soluble in water; suitable for solid and liquid matrices |
| Finished Product Applications | Dietary supplements (tablets, hard capsules, softgels, sachets) & functional food / liquid beverages |
| Regulatory & Quality Status | ISO 9001, ISO 14001, GMP Quality Assurance, Non-GMO, Halal & Kosher compliant |
Scientific Bibliography & Clinical Evidence
1. Wattanathorn J. et al. (2008). Positive modulation of cognition and mood in the healthy elderly volunteer following the administration of Centella asiatica. Journal of Ethnopharmacology, 116(2): 325-332. [Randomized, double-blind, placebo-controlled study demonstrating improved reaction time, memory, and calmness in elderly subjects.]
2. Gray N.E. et al. (2018). Centella asiatica increases hippocampal synaptic density and improves memory and executive function. Brain and Behavior, 8(7): e01024.
3. Chanana P. & Kumar A. (2016). Possible Involvement of Nitric Oxide Modulatory Mechanisms in the Neuroprotective Effect of Centella asiatica. Phytotherapy Research, 30(4): 671-680.
4. Sari D.C.R. et al. (2019). Centella asiatica ethanol extract up-regulates hippocampal BDNF, TrkB and ERK1/2 signaling in stress models. Iranian Journal of Basic Medical Sciences, 22(10): 1218-1224.
5. Dhanasekaran M. et al. (2009). Centella asiatica extract selectively decreases amyloid beta levels in hippocampus. Phytotherapy Research, 23(1): 14-19.
Formulate Superior Nootropic Products with CENTELLORY®
Request technical datasheets, full clinical study dossiers, sample quantities, or batch pricing from our botanical specialists.